Cephradine Capsules and cefaclor capsules What is the difference
women-men-children healthcare
2010-1-9 2:36:53
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Cephradine Cephradine
??Cefradine (Cephradine, Velosef)
??Cephradine Structure
??Synonym: Vanguard ADM Ⅵ, cephalosporins Ⅵ, Pioneer Ryding, cephalosporin Latin, cephalosporin grip determined cephalosporin Reddin, had ring amine Abamectin, cephalosporin Cyclohexene, Cyclohexene amine cephalosporins, ring-ene Cephalosporium Su.
??【Function and Uses】
??This product is the first-generation semi-synthetic cephalosporin antibiotic similar to the role and cephalexin. This product acid can be given orally, absorption is good, a higher plasma concentration, is characterized by resistance to β-lactamase of Staphylococcus aureus and other multi-drug resistance to the broad-spectrum antibiotic-resistant bacteria such as the rapid and reliable sterilization, prototype mainly excreted through the urine, the higher the concentration of urine. Mainly used in clinical respiratory tract, urinary tract, skin and soft tissue infections, such as bronchitis, pneumonia, pyelonephritis, cystitis, ENT infections, enteritis, and dysentery.
??【Usage】 dose and
??Oral, adult, 0.25g ~ 0.5g / times, 6 hours times / day, day maximum 4g (16 capsules). Children according to the weight a 6.25 ~ 12.5mg/kg, every 6 hours. Intramuscular or intravenous, adult, 0.25g ~ 0.5g / times, 3 to 4 times / day. Severe infection may be increased to a daily 4g.
??【Side-effects and Cautions】
??An adverse reaction to occasional gastrointestinal disorders, such as nausea, vomiting, diarrhea and rash, urticaria, and so on. Long-term use can result in flora imbalance, double infection, and vitamin deficiency.
??2, and some cross-penicillin allergic to penicillin allergy or those who have allergies with caution.
??3 food can delay absorption of this product does not affect the absorption of the total, but should an empty stomach
??【Preparation】 capsule; each capsule 0.25g; 0.5g. Dry Suspension: 0.125g; 0.25g.
??Injection cefradine (add sodium carbonate): a bottle of 0.5g; 1g.
??Injection cefradine A (Add a Arg): a bottle of 0.5g; 1g.
??【Storage】 France dry, cool place, avoid heat.
??Warning: About hematuria
??China SFDA: vigilance aciclovir and cephradine adverse reactions http://www.sina.com.cn 2009 Nian 01 Yue 12 Ri 12:54 China News Net
??BEIJING, January 12 Xinhua news According to the State Food and Drug Administration Web site, recently, the State Food and Drug Administration under the National Adverse Drug Reaction Monitoring Center's report reminded medical workers, drug production enterprises and the general public vigilance Xi Luo A Wei and cephradine adverse reactions.
??National Adverse Drug Reaction Monitoring Center database, case report data show that aciclovir led to acute renal damage and cause hematuria Cefradine problems still outstanding.
??For medical workers, pharmaceutical manufacturing enterprises and the public understanding of this situation, the State Food and Drug Administration to remind the majority of clinicians in choosing medication should be adequate benefit / risk analysis and close attention to the process of medication Xi Luo A Wei and cephradine serious adverse reaction; related manufacturing enterprises respond to acyclovir can cause acute renal damage and Cefradine the mechanism leading to the occurrence of hematuria in-depth research, comprehensive evaluation of these two types of benefits / risks, to take timely and effective measures to minimize of similar adverse drug reactions to repeat itself, to protect the public safety of drug use.
??State Food and Drug Administration will continue to be concerned about the types of security issues, and timely feedback information, the protection of public safety of drug use to play its due role.
Cefaclor cefaclor
??Cefaclor (Ceclor)
??Synonym: Cephalosporium benzyl ammonium chloride, the Greek carved workers benzyl ammonium chloride monohydrate cephalosporin, cefaclor
??Cefaclor tablets Instructions Please read the instructions and under the guidance of the physician to use.
??【Drug name】
??Common name: cefaclor tablets
??The English name: Cefaclor Tablets
??Pinyin: Toubaokeluo Pian
??【Composition】
??Chemical Name: (6R, 7R) -7 - [(R) -2 - amino--2 - phenyl acetyl-amino] -3 - chloro--8 - oxo -5 - Sulfur miscellaneous -1 - azabicyclo [4.2. 0] Xin -2 - ene -2 - carboxylic acid monohydrate.
??Molecular formula: C15H14ClN3O4S ? H2O
??MW: 385.82
??【Properties】
??This product is film-coated tablets, except coated white to pale yellow after the obvious.
??【Indications】
??Clinical application of the following infections caused by susceptible strains:
??1. Respiratory tract infections: such as laryngitis, tonsillitis, bronchitis and pneumonia.
??2. Er Section infections: such as otitis media.
??3. Urinary tract infection: such as pyelonephritis, bladder Yandeng.
??4. Skin and soft tissue infections: such as cellulitis, furuncle, subcutaneous abscess, folliculitis, mastitis and so on.
??5. Other: sty, periodontal tissue inflammation, inflammation around the crown, palatal inflammation, scarlet fever and so on.
??【Specification】
??0.25g (by C15H14ClN3O4S terms)
??【Usage consumption】
??Usage: Oral.
??Dosage:
??Adults: one 0.25g, day 3 times. Dose may be doubled in patients with severe infection, but the day the total does not exceed 4g.
??Children: according to the weight on the 1st 20 ~ 40mg/kg, points three times to give, but the day the total does not exceed 1g.
??In patients with renal insufficiency the dose recommended: creatinine clearance rate 10-50ml/min, use the normal dose of 50% -100%; creatinine clearance rate of less than 10ml/min, the normal dose halved.
??Adverse reactions 【】
??1. More common gastrointestinal reactions: soft then, diarrhea, stomach discomfort, loss of appetite, nausea, vomiting, belching and so on.
??2. Serum sickness-like reactions more common than those of other antibiotics, especially common in children, typical symptoms include skin reactions and joint pain.
??3. Allergic reactions: rash, urticaria, eosinophilic granulocytes increased vulva pruritus.
??4. Occasionally other: Serum aminotransferase, blood urea nitrogen and creatinine slightly elevated, proteinuria, urine and other tube.
??【Taboo】
??For this product and other cephalosporins allergy banned.
??【Note】
??1. This product is with penicillin or a cephamycin (Cephamycin) are cross-allergic reaction, so penicillin, penicillin derivatives, penicillamine, and cephamycin allergy caution.
??2. Those used with caution in liver dysfunction.
??3. Severe renal insufficiency or completely Sang Shizhe, usage of blood drug concentration monitoring should be carried out.
??4. There is a history of gastrointestinal disease, particularly ulcerative colitis, regional enteritis, or antibiotic-associated colitis were used with caution.
??5. It can be used long-term use disorders caused by bacteria, triggering secondary infections.
??6. Of laboratory indicators of interference: anti-globulin (Coombs) test, there may be positive; copper sulfate urine sugar test may be false positive was, but the enzyme glucose test method will not be affected; serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and blood urea nitrogen may be increased; using Jaffe reaction measured in serum and urine creatinine values may have a false increase.
??7. This product should fasting oral, food does not affect the total absorption of goods, but can be slightly delayed time to peak and lower peak concentrations. Milk does not affect the absorption of this product.
??【Pregnant and lactating women drug】
??1. It can be used through the placenta, pregnant women should be used with caution.
??2. This product can be discharged through the milk, so breast-feeding women should be used with caution or suspension of breast-feeding.
??Pediatric Use
??Neonatal drug safety has not been established.
??【Old medication】
??Elderly patients should be under the guidance of physicians adjust according to renal function, or medication dosage interval.
??【Drug interactions】
??1. Furosemide, ethacrynic acid, bumetanide and so strong diuretic drug, BCNU, streptozocin, and aminoglycoside antibiotics, such as anti-tumor drugs such as renal toxicity of this product combined with an increase in the possibility of renal toxicity.
??2. Clavulanic acid can enhance the product in some of the produce β-lactamase and the resistance of this product of Gram-negative bacilli antimicrobial activity.
??3. This product enables oral probenecid plasma concentration levels and delay the increase in the excretion of this product.
??Overdosage
??Overdose symptoms include nausea, vomiting and diarrhea.
??Excessive response to treatment as follows:
??1. You need to use adrenaline severe acute allergic reaction, or other drugs intended to epinephrine, antihistamines or corticosteroids, if necessary, needs to increase with anti-convulsive drugs.
??2. Severe diarrhea need to add water, electrolytes and protein. Should not be used to reduce peristalsis of the antidiarrheal agent, can be oral vancomycin, metronidazole, bacitracin, or cholestyramine.
??3. Hemodialysis or peritoneal dialysis will help clear the drugs in serum.
??【Pharmacology and toxicology】
??This product is broad-spectrum semi-synthetic cephalosporin antibiotics. Pairs of penicillinase-producing Staphylococcus aureus, A group hemolytic streptococcus, Streptococcus viridans and Staphylococcus epidermidis activity and Cefadroxil same as for non-producing enzyme of Staphylococcus aureus and pneumococcus antibacterial effect than cefadroxil 2 ~ 4 times as strong. Against Gram-negative bacteria including Escherichia coli and Klebsiella pneumoniae bacteria stronger activity than cephalexin, and cefadroxil similar to that of Proteus mirabilis, Salmonella and Shigella species than the activity of cefadroxil strong . 2.9 ~ 8mg / L of the product can inhibit all of Haemophilus influenzae, including ampicillin-resistant strains. Moraxella catarrhalis, and Neisseria gonorrhoeae is very sensitive to this product. Indole-positive Proteus, Serratia, Acinetobacter and Pseudomonas aeruginosa were resistant to this product. Mechanism of action of this product is to inhibit bacterial cell wall synthesis.
??Pharmacokinetics】
??This product rapidly from the intestine after oral absorption, distribution in body tissues. This product is 500mg oral peak plasma concentration (Cmax) of approximately 13.44 mg / L, peak time (tmax) of approximately 0.56 hours, the blood elimination half-life (t1/2β) for 0.57 hours. This product is pus in the middle ear can be an adequate concentration; in high concentrations in saliva and tears. This product is the serum protein binding rate is about 25%. Delivery volume of about 15% of the in vivo metabolism. This product is mainly from the renal excretion of 8-hour dose volume of about 77% of the prototype from the urine excreted in urine drug concentration is high; about 0.05% since the bile excretion, bile concentrations lower than plasma concentrations. Hemodialysis can remove some of the product.
??【Storage】
??Shading, sealed, in cool and dark (no more than 20 ℃) dry place to save.
??【Packing】
??Pairs of aluminum packaging, each plate six, pack a plate.
??【Valid Period】
??24 months
??【Executive Standard】
??"Chinese Pharmacopoeia" 2005 Edition 2
References: http://baike.baidu.com/view/96768.htm?fr=ala0_1 http://baike.baidu.com/view/96887.htm?fr=ala0_1 # -0 - #
==========================
sp pull will be the first generation cephalosporins, cefaclor is a second-generation cephalosporins, first-generation cephalosporins against positive bacterial infections and effective, the second-generation cephalosporin-positive bacterial infections of the effect of somewhat less-negative bacteria but effective, that is, a wide range of second-generation anti-bacterial
Cephradine
??Cefradine (Cephradine, Velosef)
??Synonym: Vanguard ADM Ⅵ, cephalosporins Ⅵ, Pioneer Ryding, cephalosporin Latin, cephalosporin grip determined cephalosporin Reddin, had ring amine Abamectin, cephalosporin Cyclohexene, Cyclohexene amine cephalosporins, ring-ene Cephalosporium Su.
??【Function and Uses】
??This product is the first-generation semi-synthetic cephalosporin antibiotic similar to the role and cephalexin. This product acid can be given orally, absorption is good, a higher plasma concentration, is characterized by resistance to β-lactamase of Staphylococcus aureus and other multi-drug resistance to the broad-spectrum antibiotic-resistant bacteria such as the rapid and reliable sterilization, prototype mainly excreted through the urine, the higher the concentration of urine. Mainly used in clinical respiratory tract, urinary tract, skin and soft tissue infections, such as bronchitis 【Usage and Dosage】 oral adult time 0.25 ~ 0.5g, every 6 hours one time a day the highest dose of 4g. Children, according to the weight a 25 ~ 50mg/kg, 1 times the maximum dose of 0.3 grams. Every 6 hours a time.
??】 【Adverse reactions adverse reactions to this product lighter, and lower incidence of about 6%. Nausea, vomiting, diarrhea, upper abdominal discomfort is more common gastrointestinal reactions. The incidence of drug eruption about 1% ~ 3%, pseudomembranous colitis, eosinophilia, direct Coombs test was positive reaction, peripheral blood leukocyte and neutrophil as the decrease in seen in individual patients. A small number of patients, there may be a temporary increase in blood urea nitrogen, serum aminotransferase, serum alkaline phosphatase a transient increase.
??】 【Taboo against cephalosporins penicillin allergy and those with anaphylactic shock, or a history of immediate reaction to the FDA ban, pneumonia, pyelonephritis, cystitis, ENT infections, enteritis, and dysentery.
?Cefaclor
【Indications】 mainly caused by susceptible strains respiratory system, urinary system, ENT and skin and soft tissue infections.
??【Usage and Dosage】 Oral: Adult usual dose once a 0.25g, day 3 times. Dose may be doubled in patients with severe infection, but does not exceed the total daily 4.0g. Or the doctor's advice.
??Adverse reactions 【】 1. The gastrointestinal tract: diarrhea, stomach discomfort, nausea and vomiting. 2. Allergic reactions: urticaria, rash, eosinophilia, external genital itching. 3. Other: aminotransferase, plasma urea nitrogen (BUN) and creatinine (Cr) slightly increased, proteinuria, casts and so on.
??】 【Taboo banned for Cephalosporin allergy.
??【Note】 penicillin allergy, renal function were used with caution in serious injury.
??【Pregnant and lactating women drug】 pregnant and lactating women with caution.
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==========================
Cephradine Cephradine
??Cefradine (Cephradine, Velosef)
??Cephradine Structure
??Synonym: Vanguard ADM Ⅵ, cephalosporins Ⅵ, Pioneer Ryding, cephalosporin Latin, cephalosporin grip determined cephalosporin Reddin, had ring amine Abamectin, cephalosporin Cyclohexene, Cyclohexene amine cephalosporins, ring-ene Cephalosporium Su.
??【Function and Uses】
??This product is the first-generation semi-synthetic cephalosporin antibiotic similar to the role and cephalexin. This product acid can be given orally, absorption is good, a higher plasma concentration, is characterized by resistance to β-lactamase of Staphylococcus aureus and other multi-drug resistance to the broad-spectrum antibiotic-resistant bacteria such as the rapid and reliable sterilization, prototype mainly excreted through the urine, the higher the concentration of urine. Mainly used in clinical respiratory tract, urinary tract, skin and soft tissue infections, such as bronchitis, pneumonia, pyelonephritis, cystitis, ENT infections, enteritis, and dysentery.
??【Usage】 dose and
??Oral, adult, 0.25g ~ 0.5g / times, 6 hours times / day, day maximum 4g (16 capsules). Children according to the weight a 6.25 ~ 12.5mg/kg, every 6 hours. Intramuscular or intravenous, adult, 0.25g ~ 0.5g / times, 3 to 4 times / day. Severe infection may be increased to a daily 4g.
??【Side-effects and Cautions】
??An adverse reaction to occasional gastrointestinal disorders, such as nausea, vomiting, diarrhea and rash, urticaria, and so on. Long-term use can result in flora imbalance, double infection, and vitamin deficiency.
??2, and some cross-penicillin allergic to penicillin allergy or those who have allergies with caution.
??3 food can delay absorption of this product does not affect the absorption of the total, but should an empty stomach
??【Preparation】 capsule; each capsule 0.25g; 0.5g. Dry Suspension: 0.125g; 0.25g.
??Injection cefradine (add sodium carbonate): a bottle of 0.5g; 1g.
??Injection cefradine A (Add a Arg): a bottle of 0.5g; 1g.
??【Storage】 France dry, cool place, avoid heat.
??Warning: About hematuria
??China SFDA: vigilance aciclovir and cephradine adverse reactions http://www.sina.com.cn 2009 Nian 01 Yue 12 Ri 12:54 China News Net
??BEIJING, January 12 Xinhua news According to the State Food and Drug Administration Web site, recently, the State Food and Drug Administration under the National Adverse Drug Reaction Monitoring Center's report reminded medical workers, drug production enterprises and the general public vigilance Xi Luo A Wei and cephradine adverse reactions.
??National Adverse Drug Reaction Monitoring Center database, case report data show that aciclovir led to acute renal damage and cause hematuria Cefradine problems still outstanding.
??For medical workers, pharmaceutical manufacturing enterprises and the public understanding of this situation, the State Food and Drug Administration to remind the majority of clinicians in choosing medication should be adequate benefit / risk analysis and close attention to the process of medication Xi Luo A Wei and cephradine serious adverse reaction; related manufacturing enterprises respond to acyclovir can cause acute renal damage and Cefradine the mechanism leading to the occurrence of hematuria in-depth research, comprehensive evaluation of these two types of benefits / risks, to take timely and effective measures to minimize of similar adverse drug reactions to repeat itself, to protect the public safety of drug use.
??State Food and Drug Administration will continue to be concerned about the types of security issues, and timely feedback information, the protection of public safety of drug use to play its due role.
Cefaclor cefaclor
??Cefaclor (Ceclor)
??Synonym: Cephalosporium benzyl ammonium chloride, the Greek carved workers benzyl ammonium chloride monohydrate cephalosporin, cefaclor
??Cefaclor tablets Instructions Please read the instructions and under the guidance of the physician to use.
??【Drug name】
??Common name: cefaclor tablets
??The English name: Cefaclor Tablets
??Pinyin: Toubaokeluo Pian
??【Composition】
??Chemical Name: (6R, 7R) -7 - [(R) -2 - amino--2 - phenyl acetyl-amino] -3 - chloro--8 - oxo -5 - Sulfur miscellaneous -1 - azabicyclo [4.2. 0] Xin -2 - ene -2 - carboxylic acid monohydrate.
??Molecular formula: C15H14ClN3O4S ? H2O
??MW: 385.82
??【Properties】
??This product is film-coated tablets, except coated white to pale yellow after the obvious.
??【Indications】
??Clinical application of the following infections caused by susceptible strains:
??1. Respiratory tract infections: such as laryngitis, tonsillitis, bronchitis and pneumonia.
??2. Er Section infections: such as otitis media.
??3. Urinary tract infection: such as pyelonephritis, bladder Yandeng.
??4. Skin and soft tissue infections: such as cellulitis, furuncle, subcutaneous abscess, folliculitis, mastitis and so on.
??5. Other: sty, periodontal tissue inflammation, inflammation around the crown, palatal inflammation, scarlet fever and so on.
??【Specification】
??0.25g (by C15H14ClN3O4S terms)
??【Usage consumption】
??Usage: Oral.
??Dosage:
??Adults: one 0.25g, day 3 times. Dose may be doubled in patients with severe infection, but the day the total does not exceed 4g.
??Children: according to the weight on the 1st 20 ~ 40mg/kg, points three times to give, but the day the total does not exceed 1g.
??In patients with renal insufficiency the dose recommended: creatinine clearance rate 10-50ml/min, use the normal dose of 50% -100%; creatinine clearance rate of less than 10ml/min, the normal dose halved.
??Adverse reactions 【】
??1. More common gastrointestinal reactions: soft then, diarrhea, stomach discomfort, loss of appetite, nausea, vomiting, belching and so on.
??2. Serum sickness-like reactions more common than those of other antibiotics, especially common in children, typical symptoms include skin reactions and joint pain.
??3. Allergic reactions: rash, urticaria, eosinophilic granulocytes increased vulva pruritus.
??4. Occasionally other: Serum aminotransferase, blood urea nitrogen and creatinine slightly elevated, proteinuria, urine and other tube.
??【Taboo】
??For this product and other cephalosporins allergy banned.
??【Note】
??1. This product is with penicillin or a cephamycin (Cephamycin) are cross-allergic reaction, so penicillin, penicillin derivatives, penicillamine, and cephamycin allergy caution.
??2. Those used with caution in liver dysfunction.
??3. Severe renal insufficiency or completely Sang Shizhe, usage of blood drug concentration monitoring should be carried out.
??4. There is a history of gastrointestinal disease, particularly ulcerative colitis, regional enteritis, or antibiotic-associated colitis were used with caution.
??5. It can be used long-term use disorders caused by bacteria, triggering secondary infections.
??6. Of laboratory indicators of interference: anti-globulin (Coombs) test, there may be positive; copper sulfate urine sugar test may be false positive was, but the enzyme glucose test method will not be affected; serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and blood urea nitrogen may be increased; using Jaffe reaction measured in serum and urine creatinine values may have a false increase.
??7. This product should fasting oral, food does not affect the total absorption of goods, but can be slightly delayed time to peak and lower peak concentrations. Milk does not affect the absorption of this product.
??【Pregnant and lactating women drug】
??1. It can be used through the placenta, pregnant women should be used with caution.
??2. This product can be discharged through the milk, so breast-feeding women should be used with caution or suspension of breast-feeding.
??Pediatric Use
??Neonatal drug safety has not been established.
??【Old medication】
??Elderly patients should be under the guidance of physicians adjust according to renal function, or medication dosage interval.
??【Drug interactions】
??1. Furosemide, ethacrynic acid, bumetanide and so strong diuretic drug, BCNU, streptozocin, and aminoglycoside antibiotics, such as anti-tumor drugs such as renal toxicity of this product combined with an increase in the possibility of renal toxicity.
??2. Clavulanic acid can enhance the product in some of the produce β-lactamase and the resistance of this product of Gram-negative bacilli antimicrobial activity.
??3. This product enables oral probenecid plasma concentration levels and delay the increase in the excretion of this product.
??Overdosage
??Overdose symptoms include nausea, vomiting and diarrhea.
??Excessive response to treatment as follows:
??1. You need to use adrenaline severe acute allergic reaction, or other drugs intended to epinephrine, antihistamines or corticosteroids, if necessary, needs to increase with anti-convulsive drugs.
??2. Severe diarrhea need to add water, electrolytes and protein. Should not be used to reduce peristalsis of the antidiarrheal agent, can be oral vancomycin, metronidazole, bacitracin, or cholestyramine.
??3. Hemodialysis or peritoneal dialysis will help clear the drugs in serum.
??【Pharmacology and toxicology】
??This product is broad-spectrum semi-synthetic cephalosporin antibiotics. Pairs of penicillinase-producing Staphylococcus aureus, A group hemolytic streptococcus, Streptococcus viridans and Staphylococcus epidermidis activity and Cefadroxil same as for non-producing enzyme of Staphylococcus aureus and pneumococcus antibacterial effect than cefadroxil 2 ~ 4 times as strong. Against Gram-negative bacteria including Escherichia coli and Klebsiella pneumoniae bacteria stronger activity than cephalexin, and cefadroxil similar to that of Proteus mirabilis, Salmonella and Shigella species than the activity of cefadroxil strong . 2.9 ~ 8mg / L of the product can inhibit all of Haemophilus influenzae, including ampicillin-resistant strains. Moraxella catarrhalis, and Neisseria gonorrhoeae is very sensitive to this product. Indole-positive Proteus, Serratia, Acinetobacter and Pseudomonas aeruginosa were resistant to this product. Mechanism of action of this product is to inhibit bacterial cell wall synthesis.
??Pharmacokinetics】
??This product rapidly from the intestine after oral absorption, distribution in body tissues. This product is 500mg oral peak plasma concentration (Cmax) of approximately 13.44 mg / L, peak time (tmax) of approximately 0.56 hours, the blood elimination half-life (t1/2β) for 0.57 hours. This product is pus in the middle ear can be an adequate concentration; in high concentrations in saliva and tears. This product is the serum protein binding rate is about 25%. Delivery volume of about 15% of the in vivo metabolism. This product is mainly from the renal excretion of 8-hour dose volume of about 77% of the prototype from the urine excreted in urine drug concentration is high; about 0.05% since the bile excretion, bile concentrations lower than plasma concentrations. Hemodialysis can remove some of the product.
??【Storage】
??Shading, sealed, in cool and dark (no more than 20 ℃) dry place to save.
??【Packing】
??Pairs of aluminum packaging, each plate six, pack a plate.
??【Valid Period】
??24 months
??【Executive Standard】
??"Chinese Pharmacopoeia" 2005 Edition 2
References: http://baike.baidu.com/view/96768.htm?fr=ala0_1 http://baike.baidu.com/view/96887.htm?fr=ala0_1 # -0 - #
==========================
sp pull will be the first generation cephalosporins, cefaclor is a second-generation cephalosporins, first-generation cephalosporins against positive bacterial infections and effective, the second-generation cephalosporin-positive bacterial infections of the effect of somewhat less-negative bacteria but effective, that is, a wide range of second-generation anti-bacterial
Cephradine
??Cefradine (Cephradine, Velosef)
??Synonym: Vanguard ADM Ⅵ, cephalosporins Ⅵ, Pioneer Ryding, cephalosporin Latin, cephalosporin grip determined cephalosporin Reddin, had ring amine Abamectin, cephalosporin Cyclohexene, Cyclohexene amine cephalosporins, ring-ene Cephalosporium Su.
??【Function and Uses】
??This product is the first-generation semi-synthetic cephalosporin antibiotic similar to the role and cephalexin. This product acid can be given orally, absorption is good, a higher plasma concentration, is characterized by resistance to β-lactamase of Staphylococcus aureus and other multi-drug resistance to the broad-spectrum antibiotic-resistant bacteria such as the rapid and reliable sterilization, prototype mainly excreted through the urine, the higher the concentration of urine. Mainly used in clinical respiratory tract, urinary tract, skin and soft tissue infections, such as bronchitis 【Usage and Dosage】 oral adult time 0.25 ~ 0.5g, every 6 hours one time a day the highest dose of 4g. Children, according to the weight a 25 ~ 50mg/kg, 1 times the maximum dose of 0.3 grams. Every 6 hours a time.
??】 【Adverse reactions adverse reactions to this product lighter, and lower incidence of about 6%. Nausea, vomiting, diarrhea, upper abdominal discomfort is more common gastrointestinal reactions. The incidence of drug eruption about 1% ~ 3%, pseudomembranous colitis, eosinophilia, direct Coombs test was positive reaction, peripheral blood leukocyte and neutrophil as the decrease in seen in individual patients. A small number of patients, there may be a temporary increase in blood urea nitrogen, serum aminotransferase, serum alkaline phosphatase a transient increase.
??】 【Taboo against cephalosporins penicillin allergy and those with anaphylactic shock, or a history of immediate reaction to the FDA ban, pneumonia, pyelonephritis, cystitis, ENT infections, enteritis, and dysentery.
?Cefaclor
【Indications】 mainly caused by susceptible strains respiratory system, urinary system, ENT and skin and soft tissue infections.
??【Usage and Dosage】 Oral: Adult usual dose once a 0.25g, day 3 times. Dose may be doubled in patients with severe infection, but does not exceed the total daily 4.0g. Or the doctor's advice.
??Adverse reactions 【】 1. The gastrointestinal tract: diarrhea, stomach discomfort, nausea and vomiting. 2. Allergic reactions: urticaria, rash, eosinophilia, external genital itching. 3. Other: aminotransferase, plasma urea nitrogen (BUN) and creatinine (Cr) slightly increased, proteinuria, casts and so on.
??】 【Taboo banned for Cephalosporin allergy.
??【Note】 penicillin allergy, renal function were used with caution in serious injury.
??【Pregnant and lactating women drug】 pregnant and lactating women with caution.
